Patricia Y. Riley; Bruno B. Chomel
Posted: 03/15/2005; Emerging Infectious Diseases. 2005;11(1) © 2005 Centers for Disease Control and Prevention (CDC) http://www.medscape.com/viewarticle/500685
Abstract and Introduction
Exotic pets, including hedgehogs, have become popular in recent years among pet owners, especially in North America. Such animals can carry and introduce zoonotic agents, a fact well illustrated by the recent outbreak of monkeypox in pet prairie dogs. We reviewed known and potential zoonotic diseases that could be carried and transmitted by pet hedgehogs or by wild-caught hedgehogs that have been rescued.
Pets play an important role in societies throughout the world. They are important companions in many households, contributing to the physical, social and emotional development of children and the well-being of their owners, especially the elderly. Although pets offer significant benefits, potential hazards are associated with pet ownership. Exotic animals are increasingly being invited into homes as pets. However, neither pet owners nor nonveterinary healthcare providers are sufficiently knowledgeable about the potential of many of these animals to transmit zoonotic diseases.
Hedgehogs are small, nocturnal, spiny-coated insectivores that have been gaining popularity as exotic pets. These animals are considered to be unique, low-maintenance pets, and an estimated 40,000 households in the United States now own them. These animals originally arrived from Europe, Asia, and Africa, and although several species exist, 2 in particular are commonly seen as pets: the European hedgehog, Erinaceus europaeus , and the smaller African pygmy hedgehog, Atelerix albiventris . The importation of these pets from Africa to the United States has been prohibited since 1991 (Title 9 Code of Federal Regulations Section 93.701) due to their potential to carry foot-and-mouth disease, a foreign animal disease of serious economic concern to the livestock industry. In the United States, persons who sell hedgehogs are required to have a U.S. Department of Agriculture (USDA) license ( http://www.nal.usda.gov/awic/newsletters/v9n1/9n1aphis.htm ). In some states, such as Arizona, California ( http://www.dfg.ca.gov/licensing/pdffiles/fg1518.pdf ), Georgia, Hawaii, Maine, Pennsylvania, Vermont, and Washington D.C., owning a hedgehog as a pet is illegal ( www.hedgehogwelfare.org ), as is the case in some of New York City boroughs (Manhattan, Brooklyn, Queens, Bronx, Staten Island) (source: http://www.petfinder.org/shelters/CT171.html ).
Hedgehogs live in a variety of habitats where they dig their own burrows, spend most of the daylight hours asleep, and emerge at night to forage. Hedgehogs are characterized by short, grooved spines covering the entire dorsum of the body. When frightened by an unfamiliar sound or movement, the animal rolls into a tight ball. In this defensive posture, the hedgehog brings its snout and limbs close under its body, causing the spines to become erect. The spines, modified hairs having a spongy matrix and outer keratinous shaft, are not barbed. The spines rarely cause serious injury to handlers but can readily penetrate the skin. However, 1 report described 3 patients in whom an acute, transient, urticarial reaction developed after contact with the extended spines of pet hedgehogs.
Hedgehogs display an unusual behavior called “anting” or “anointing”. When first encountering a new or interesting object or food, the animal will lick the substance repeatedly until a frothy saliva forms in its mouth. The animal then rubs the excess saliva and froth onto its skin and spines. This behavior may cause saliva to accumulate on the spines, making the hedgehog less palatable to predators.
In addition to the contact urticaria that has been reported in some hedgehog handlers, hedgehogs pose a risk for a number of potential zoonotic diseases. Major microbial infections associated with hedgehogs include bacteria such as Salmonella and Mycobacteria , as well as some fungal and viral diseases. Many disease conditions can cause immunodeficiency in humans; the most notable is AIDS. Similarly, immunosuppressive strategies employed to prevent rejection of bone marrow or solid organ transplants render such patients extremely susceptible to viral and mycobacterial infections. An increasing percentage of the population is becoming susceptible to severe diseases associated with exotic pet ownership, as illustrated by the recent monkeypox outbreak in pet prairie dogs. Immunocompromised persons may be at increased risk for infections from hedgehogs and should be particularly careful.
The following review focuses on the zoonotic or potentially zoonotic agents carried by hedgehogs ( Table ). The risks are particularly of concern for people rescuing wild-caught hedgehogs and adopting them as pets. We distinguished major established zoonotic infections, such as salmonellosis or ringworm, from other less common or potential zoonoses carried by hedgehogs.
Table. Zoonotic and Potentially Zoonotic Viral, Bacterial, Protozoal, and Mycotic Zoonoses of Hedgehogs
|I. Confirmed zoonotic diseases carried by hedgehogs:||II. Potential zoonotic diseases carried by hedgehogs:|
Herpesvirus, including human herpes simplex
Crimean-Congo hemorrhagic fever
|Mycotic||Trychophyton mentagrophytes var. erinacei*
*Most common zoonoses.
- Robertson ID, Irwin PJ, Lymbery AJ, Thompson RC. The role of companion animals in the emergence of parasitic zoonoses. Int J Parasitol. 2000;30:1369-77.
- Rosen T, Jablon J. Infectious threats from exotic pets: dermatological implications. Dermatol Clin. 2003;21:229-36.
- Hoefer HL. Hedgehogs. Vet Clin North Am Small Anim Pract. 1994;24:113-20.
- Woodward D, Khakhria R, Johnson W. Human salmonellosis associated with exotic pets. J Clin Microbiol. 1997;35:2786-90.
- Blakeley K. Forget Fido. Forbes. August 7, 2000;152.
- Centers for Disease Control. African pygmy hedgehog-associated salmonellosisWashington, 1994. MMWR Morb Mortal Wkly Rep. 1995;44:462-3.
- Fairley JA, Suchniak J, Paller AS. Hedgehog hives. Arch Dermatol. 1999;135:561-3.
- Ellis C, Mori M. Skin diseases of rodents and small exotic mammals. Vet Clin North Am Exot Anim Pract. 2001;4:493-542.
- Maertens J, Vrebos M, Boogaerts M. Assessing risk factors for systemic fungal infections. Eur J Cancer Care (Engl). 2001;10:56-62.
- Centers for Disease Control and Prevention. Update: multistate outbreak of monkeypoxIllinois, Indiana, Kansas, Missouri,Ohio, and Wisconsin, 2003. MMWR Morb Mortal Wkly Rep. 2003;52:642-6.
- Isenbugel E, Baumgartner R. Diseases of the Hedgehog In: Fowler M, editor. Zoo and wild animal medicine 3rd ed. Philadelphia: WB Saunders Company; 1993.
- Craig C, Styliadis S, Woodward D, Werker D. African pygmy hedgehogassociated Salmonella tilene in Canada. Can Commun Dis Rep. 1997;23:129-2.
- Handeland K, Refsum T, Johansen BS, Holstad G, Knutsen G, Solberg I, Schulze J, Kapperud G. Prevalence of Salmonella typhimurium infection in Norwegian hedgehog populations associated with two human disease outbreaks. Epidemiol Infect. 2002;128:523-7.
- Keymer IF, Gibson EA, Reynolds DJ. Zoonoses and other findings in hedgehogs ( Erinaceus europaeus ): a survey of mortality and review of the literature. Vet Rec. 1991;128:245-9.
- Tappe JP, Weitzman I, Liu S, Dolensek EP, Karp D. Systemic Mycobacterium marinum infection in a European hedgehog. J Am Vet Med Assoc. 1983;183:1280-1.
- Heineman HS, Spitzer S, Pianphongsant T. Fish tank granuloma. A hobby hazard. Arch Intern Med. 1972;130:121-3.
- Duplantier JM, Duchemin JB, Chanteau S, Carniel E. From the recent lessons of the Malagasy foci towards a global understanding of the factors involved in plague re-emergence. Vet. Res.36. In press 2005.
- Sixl W, Kock M, Withalm H, Stunzner D. Serological investigations of the hedgehog ( Erinaceus europaeus ) in Styria. 2.Report. Geogr Med Suppl. 1989;2:105-8.
- Gregory MW, English MP. Arthroderma benhamiae infection in the Central African hedgehog Erinaceus albiventris , and a report of a human case. Mycopathologia. 1975;55:143-7.
- Philpot CM, Bowen RG. Hazards from hedgehogs: two case reports with a survey of the epidemiology of hedgehog ringworm. Clin Exp Dermatol. 1992;17:156-8.
- Rosen T. Hazardous hedgehogs. South Med J. 2000;93:936-8.
- Campbell T. Intestinal candidiasis in an African hedgehog ( Atelerix albiventris ). Exotic Pet Pract. 1997;2:79.
- English MP, Gregory MW, Spence JA. Invasion by Candida albicans of the footpads of the Central African hedgehog ( Erinaceus albiventris ). Mycopathologia. 1975;55:139-41.
- Simkova A. Quantitative study of experimental Tahyna virus infection in hibernating hedgehogs. J Hyg Epidemiol Microbiol Immunol. 1966;10:499-509.
- Camicas JL, Deubel V, Heme G, Robin Y. [Ecological and nosological study of tick-borne arboviruses in Senegal. II. Experimental study of the pathogenicity of the Bhanja virus in small domestic ruminants]. Rev Elev Med Vet Pays Trop. 1981;34:257-61.
- Hubalek Z, Rodl P, Juricova Z. Experimental infection of hedgehog ( Erinaceus europaeus ) with Bhanja virus. Folia Parasitol (Praha). 1984;31:189-90.
- Kozuch O, Gresikova M, Nosek J, Lichard M, Sekeyova M. The role of small rodents and hedgehogs in a natural focus of tick-borne encephalitis. Bull World Health Organ. 1967;36(Suppl):61-6.
- Kozuch O, Nosek J. Alimentary infection of the hedgehog with tick-borne encephalitis (TE) virus. Acta Virol. 1964;21:284.
- Kozuch O, Nosek J, Ernek E, Lichard M, Albrecht P. Persistence of tick-borne encephalitis virus in hibernating hedgehogs and dormice. Acta Virol. 1963;19:430-3.
- Sidwell RW, Smee DF. Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control. Antiviral Res. 2003;57:101-11.
- Causey OR, Kemp GE, Madbouly MH, David-West TS. Congo virus from domestic livestock, African hedgehog, and arthropods in Nigeria. Am J Trop Med Hyg. 1970;19:846-50.
- Shepherd AJ, Leman PA, Swanepoel R. Viremia and antibody response of small African and laboratory animals to Crimean-Congo hemorrhagic fever virus infection. Am J Trop Med Hyg. 1989;40:541-7.
- Vizoso AD, Thomas WE. Paramyxoviruses of the morbilli group in the wild hedgehog Erinaceus europeus . Br J Exp Pathol. 1981;62:79-86.
- Stack MJ, Higgins RJ, Challoner DJ, Gregory MW. Herpesvirus in the liver of a hedgehog ( Erinaceus europaeus ). Vet Rec. 1990;127:620-1.
- Widen F, Gavier-Widen D, Nikiila T, Morner T. Fatal herpesvirus infection in a hedgehog ( Erinaceus europaeus ). Vet Rec. 1996;139:237-8.
- Allison N, Chang TC, Steele KE, Hilliard JK. Fatal herpes simplex infection in a pygmy African hedgehog ( Atelerix albiventris ). J. Comp Pathol. 2002;126:76-8.
- Farago Z. [Rabid hedgehog in inner-city area of Budapest]. Orv Hetil. 1997;138:2231-2.
- McLauchlan JD, Henderson WN. The occurrence of foot-and-mouth disease in the hedgehog under natural conditions. J Hyg (Cambridge). 1947;45:474-9.
- Macaulay J. Foot-and-mouth disease in non-domestic animals. Bull Epizootic Dis Africa. 1963;11:143-6.
- Graczyk TK, Cranfield MR, Dunning C, Strandberg JD. Fatal cryptosporidiosis in a juvenile captive African hedgehog ( Ateletrix albiventris ). J Parasitol. 1998;84:178-80.
- Centers for Disease Control and Prevention. Reptile-associated salmonellosisselected states, 1998-2002. MMWR Morb Mortal Wkly Rep. 2003;52:1206-9.